International Journal of Genetics and Genomics

Volume 7, Issue 4, December 2019

  • Prediction of Structural and Functional Effects of Single Nucleotide Polymorphisms in NAT2gene, a Computational Analysis

    Amna Elsadig Elsafi Abodlaa, Dalia Mursi, Mona Abdelrahman Mohamed Khaier, Mai Abdul RahmanMasri, Nazik Elmalaika Obaid Seid Ahmed Husain, Hind Abdelaziz Elnasri

    Issue: Volume 7, Issue 4, December 2019
    Pages: 88-97
    Received: Aug. 03, 2019
    Accepted: Oct. 04, 2019
    Published: Oct. 15, 2019
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    Abstract: N-acetyltransferase 2 (encoded by NAT2) is a phase II enzyme that detoxifies and metabolizes xenobiotics and drugs components. It is a critical enzyme in clinical pharmacology. It has remarkable genetic polymorphisms, which is associated with the risk of developing cancer due to the change of normally fast acetylation of substrates to slow acetylat... Show More
  • Incidence of Groundnut Rosette Disease (GRD) and Genetic Diversity of Groundnut Rosette Assistor Virus (GRAV) in Western Kenya

    Benard Mukoye, Millicent Florence Owuor Ndonga, Hassan Karakacha Were

    Issue: Volume 7, Issue 4, December 2019
    Pages: 98-102
    Received: Sep. 11, 2019
    Accepted: Oct. 04, 2019
    Published: Oct. 16, 2019
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    Abstract: This study determined the incidence of groundnut rosette disease (GRD) and genetic diversity of groundnut rosette assistor virus (GRAV, genus Luteovirus) in western Kenya. The diseases is a major constraint of groundnuts in Sub-Saharan Africa (SSA) causing up to 100% yield losses in severe cases. Among the GRD associated viruses, GRAV plays a cruci... Show More
  • Novel Candidate Genes for Somatic Cell Count in Frizarta Dairy Sheep

    Antonios Kominakis, Aggeliki Saridaki, George Antonakos

    Issue: Volume 7, Issue 4, December 2019
    Pages: 103-109
    Received: Jul. 18, 2019
    Accepted: Sep. 11, 2019
    Published: Oct. 21, 2019
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    Abstract: Aim of the present study was to identify genomic regions and candidate genes impacting on somatic cell count in the Frizarta dairy sheep. A total number of 482 Frizarta ewes genotyped with the medium density SNP array with available records on milk somatic cell count were used. Associations between genomic markers and the trait under study were det... Show More
  • Nanoparticles Induce Oxidative Stress in HT-29 Colon Adenocarcinoma Cell Line After 24 and 48 Hour Exposure

    Metin Budak

    Issue: Volume 7, Issue 4, December 2019
    Pages: 110-114
    Received: Aug. 31, 2019
    Accepted: Oct. 18, 2019
    Published: Oct. 26, 2019
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    Abstract: Nanoparticle research is currently an area of intense scientific research, due to a wide variety of potential applications in biomedical, optical, and electronic fields. Nanoparticles are of great scientific interest as they are effectively a bridge between bulk materials and atomic or molecular structures. Superoxide dismutase (SOD), Glutamine syn... Show More
  • Evaluation of Common Bean Cultivars Resistance to the Bean Common Mosaic Necrosis Virus in Western Kenya

    Mangeni Bonphace Collins, Ndong’a Millicent, Mukoye Benard, Were Hassan Karakacha

    Issue: Volume 7, Issue 4, December 2019
    Pages: 115-118
    Received: Oct. 01, 2019
    Accepted: Oct. 14, 2019
    Published: Nov. 15, 2019
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    Abstract: The common bean (Phaseolus vulgaris), is a high protein crop and the main legume in the cropping system of western Kenya. Despite its importance, common bean yields are low (<1.0 t/ha) and declining. Bean Common mosaic virus (BCMV) and Bean common mosaic necrosis virus (BCMNV) are the most common and most destructive and can cause a yield loss as high as 100%. In Kenya, limited cultivars and exotic genotypes with resistance to BCMV and BCMNV strains have been reported. Reports indicate BCMNV being a widespread virus compared to BCMV in western Kenya. This study therefore, sought to screen popular cultivars for resistance to the virus. Sixteen popularly grown bean cultivars together with cowpea (Vigna unguiculata), soybean (Glycine max) and groundnut (Arachis hypogaea) were planted in a green house in a completely randomized block design with three replicates. The plan... Show More
  • First Report of Cowpea Polero Virus 1 (CPPV1) Infecting Cowpea in Kenya

    Orakha Odhiambo Patrick, Hassan Were, Millicent Ndonga, Mukoye Benard

    Issue: Volume 7, Issue 4, December 2019
    Pages: 119-123
    Received: Sep. 14, 2019
    Accepted: Nov. 04, 2019
    Published: Nov. 19, 2019
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    Abstract: Cowpea is an important legume crop for nutritional security, livestock feed and source of income in Kenya. Cowpea yield in Kenya is very low and declining further due to high incidences of pests and diseases among other factors. Like other pathogens, viruses have continued to cause yield losses of up to 100% depending on the prevailing epidemiologi... Show More
  • In Silico Analysis of Single Nucleotide Polymorphisms (SNPs) in Human MPL Gene

    Mohamed Mubarak Babeker, Afra Mohamed Suliman Albakry, Mohammed Nagm Eldin Elsamani, Gihan Mossalami, Hind Abdelaziz Elnasri, Mona Abdelrahman Mohamed Khaier

    Issue: Volume 7, Issue 4, December 2019
    Pages: 124-131
    Received: Sep. 30, 2019
    Accepted: Oct. 23, 2019
    Published: Nov. 22, 2019
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    Abstract: Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. Mutations to this gene are associated with myelofibrosis and e... Show More
  • First Full Length Genome Sequence of Bean Common Mosaic Necrosis Virus (BCMNV) Isolated from Common Bean in Western Kenya

    Mangeni Bonphace Collins, Were Hassan Karakacha, Mukoye Benard, Ndong’a Milicent

    Issue: Volume 7, Issue 4, December 2019
    Pages: 132-135
    Received: Oct. 23, 2019
    Accepted: Nov. 22, 2019
    Published: Dec. 02, 2019
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    Abstract: Bean common mosaic necrosis virus (BCMNV) is one of the most common and most destructive viruses of common bean and can cause a yield loss as high as 100%. The common bean (Phaseolus vulgaris L) is an important legume crop for food and cash in Kenya. In Kenya, there is inadequate documentation on the strains of the virus infecting common bean. This... Show More
  • Ameliorative Effect of Peach Seed Extract on Cyclophosphamide- Induced Cytogenetic and Histological Effects in Mice

    Heba Mohamed Salah, Ezzat Ibrahim Aboul-Ela, Hamdy Hamed Swelim

    Issue: Volume 7, Issue 4, December 2019
    Pages: 136-147
    Received: Nov. 02, 2019
    Accepted: Nov. 22, 2019
    Published: Dec. 04, 2019
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    Abstract: Cyclophosphamide (CP) is a frequently used drug for its anticancer and immunosuppressive potential. However metabolism of CP in the body results into toxic chemical compounds (to the liver itself and other non-target vital organs) via oxidative stress, apoptosis induction and finally necrosis. Since there is no escaping of using such medications in... Show More