Implication of the Cytochrome b Mutations in the Evolution of Breast Benign Tumors Among Senegalese Women
Daniel Doupa,
Jean Luc Faye,
Fatimata Mbaye,
Sidy Ka,
Ahmadou Dem,
Mamadou Kane,
Mbacké Sembène
Issue:
Volume 3, Issue 4, August 2015
Pages:
36-42
Received:
15 July 2015
Accepted:
23 July 2015
Published:
1 August 2015
Abstract: While the studies linking the germ line mtDNA mutations to cancer raise many ambiguities because of its high genetic variability, the study of somatic mutations of this one, is proved to be decisive in the identifying of mutations involved in the genesis and evolution of tumors. In the present study, we determined the implication of the Cytochrome b mutations in the evolution of breast benign tumors among Senegalese women. This one is about, with the sequencing-PCR, to research mutations of Cytochrome b, to evaluate their importance among a benign tissues group compared to another healthy tissues group; and thence, to determine the effect of the natural selection on the observed variability. The analysis of mutations profiles of Cytochrome b in benign tissues allowed seeing that 50% of them have led to a change in amino acid and 12.5% to a shift in the reading frame. Moreover, the analysis of selection signature indicated that these mutations were subjected to a positive selection. The results also revealed that the population of benign cells was growing rapidly from an ancestral population sparse. These observations have enabled to accept the hypothesis that Cytochrome b mutations would be involved in the evolution of breast benign tumors among Senegalese women.
Abstract: While the studies linking the germ line mtDNA mutations to cancer raise many ambiguities because of its high genetic variability, the study of somatic mutations of this one, is proved to be decisive in the identifying of mutations involved in the genesis and evolution of tumors. In the present study, we determined the implication of the Cytochrome ...
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