International Journal of Genetics and Genomics

Volume 2, Issue 4, August 2014

  • Domestication and Genome Evolution

    Glazko, Valeriy, Zybaylov, Boris, Glazko, Tatiana

    Issue: Volume 2, Issue 4, August 2014
    Pages: 47-56
    Received: Jul. 18, 2014
    Accepted: Jul. 30, 2014
    Published: Aug. 10, 2014
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    Abstract: Background. Pressure on modern agriculture to increase production is rising with the increase in human population. To meet this demand it is important to effectively manage domesticated species. However, genetic mechanisms and genomic targets of domestication are still poorly understood. It is well known that phenotypic variability in domesticated ... Show More
  • Molecular Evolution of Key Receptor Genes in Primates and Non-Human Primates

    Barbara Picone, Alan Christoffels

    Issue: Volume 2, Issue 4, August 2014
    Pages: 57-61
    Received: Jul. 25, 2014
    Accepted: Aug. 06, 2014
    Published: Aug. 20, 2014
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    Abstract: African primates remain an unexplored source of information required to complete the origin and evolution of many human pathogens. Current studies have shown the importance of several receptor human genes implicated in host resistance or susceptibility to tuberculosis. The validation of these genes in Mycobacterium tuberculosis infection makes them... Show More
  • In Silico Identification of Novel Candidate Drug Targets in Haemophilus Influenzae Rd KW20

    Ranjith Kumavath, Swaraj Prasad, Pratap Devarapalli, Debmalya Barh

    Issue: Volume 2, Issue 4, August 2014
    Pages: 62-67
    Received: Jul. 21, 2014
    Accepted: Aug. 07, 2014
    Published: Aug. 20, 2014
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    Abstract: Background: Globally, respiratory diseases cause an estimated 1.9 million deaths per year. One of the most important aetiological organisms of both adult and childhood respiratory disease is Non-Typeable Haemophilus influenzae (NTHi). NTHi is frequently isolated from the respiratory tract during episodes of sinusitis, Otitis Media and pneumonia and... Show More
  • Linkage Disequilibrium and the Mapping of Human Disease Genes

    Nahid Askari, Amin Baghizadeh

    Issue: Volume 2, Issue 4, August 2014
    Pages: 68-76
    Received: Jun. 30, 2014
    Accepted: Jul. 15, 2014
    Published: Aug. 20, 2014
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    Abstract: Identification of human disease genes can be accomplished by two strategies: functional cloning and positional cloning. Genetic mapping is the localization of genes underlying phenotypes on the basis of correlation with DNA variation, without the need for prior hypotheses about biological function and the simplest form, called linkage analysis. The... Show More
  • Trisomy 19 as the Sole Chromosomal Abnormality in CML

    Salil N. Vaniawala, Pankaj K. Gadhia

    Issue: Volume 2, Issue 4, August 2014
    Pages: 77-79
    Received: Aug. 04, 2014
    Accepted: Aug. 19, 2014
    Published: Aug. 30, 2014
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    Abstract: Presence of trisomy 19 in chronic myeloid leukemia (CML) normally considered as secondary abnormality but trisomy 19 rarely occur as sole abnormality. In the present study a total of 2312 Ph positive CML were screened from year2004 to 2014 and we found 2 cases of trisomy 19 as sole karyotype abnormalities. Both karyotype showed 47,XY,t(9;22)(q34;q1... Show More