International Journal of Genetics and Genomics

Volume 5, Issue 1, February 2017

  • Persistent Circulating Immune Complexes: Potential Source of Epimutation and Cancer Poor Prognosis

    Michael Chukwudi Ezeani, Charles Chinedum Onyenekwe, Samuel Chukwuemeka Meludu

    Issue: Volume 5, Issue 1, February 2017
    Pages: 1-13
    Received: Dec. 13, 2016
    Accepted: Dec. 27, 2016
    Published: Jan. 29, 2017
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    Abstract: Estimation of serum level of circulating immune complexes and its use for monitoring treatments have been carried out extensively in various disease conditions including autoimmune diseases and cancer, but little or no work has considered persistent circulation of immune complexes consequent to physiological anomalies that could mediate epimutation... Show More
  • A Reduced Interval of Chromosome 9p21 Locus is Associated with Ischemic Stroke in Chinese Northern Han Population

    Shuo Li, Yu-Ming Xu, Hong Zheng, Edward Randell, Hai-Zheng Wang, Jianxun Cui, Guang Sun, Guangju Zhai, Fei-Yu Han, Ya-Gang Xie

    Issue: Volume 5, Issue 1, February 2017
    Pages: 14-18
    Received: Mar. 06, 2017
    Accepted:
    Published: Mar. 10, 2017
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    Abstract: The 9p21 locus, a strong risk locus for coronary arterial disease, has been also associated with other cardiovascular disease including ischemic stroke (IS) in Caucasians. However, the association between 9p21 locus and IS in Chinese Han population is still debatable because of ambiguous results reported previously. Genetic heterogeneity between So... Show More