International Journal of Genetics and Genomics

Volume 8, Issue 3, September 2020

  • Role of P53 p.Arg72Pro Variant in Recurrent Pregnancy Loss, Recurrent Implantation Failure and IVF Outcome

    Navneet Kaur, Mohamed Eltom, Karen Cheung, Siddharth Banka, Lamiya Mohiyiddeen

    Issue: Volume 8, Issue 3, September 2020
    Pages: 94-101
    Received: Jun. 17, 2020
    Accepted: Jul. 27, 2020
    Published: Sep. 08, 2020
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    Abstract: The role of p53 p.Arg72Pro variant in recurrent pregnancy loss, recurrent implantation failure and IVF outcome is controversial and research so far has yielded inconsistent results. This systematic review aims to summarise the literature on the role of TP53 p.Arg72Pro variant in recurrent pregnancy loss following natural and assisted conception. A ... Show More
  • Impact of Glucose-6-phosphate Dehydrogenase Deficiency on Sickle Cell Anaemia Expression: A Case Report

    Patrick Olanrewaju Osho, Matilda Adesuwa Osagie Ojo, Evelyn Salewa Osho, Ndidi Aisha Okunnuga, Oluwatosin Idowu Oni, Olugbenga Festus Fabusiwa

    Issue: Volume 8, Issue 3, September 2020
    Pages: 102-105
    Received: Jul. 16, 2020
    Accepted: Aug. 18, 2020
    Published: Sep. 21, 2020
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    Abstract: Sickle cell anaemia and Glucose-6-phosphate dehydrogenase deficiency have anaemia as major clinical consequence. The two disorders are rarely co-expressed in a patient. However, the pathological co-existence of both disorders tends to worsen and aggravate the clinical presentation in affected individuals. We report a diagnosis of the co-inheritance... Show More
  • Penetrance of the p53 Gene in Uterine Fibroids in Senegalese Women

    Ndime Fama, Tendeng Jacques Noël, Kénémé Bineta, Sembène Mbacké

    Issue: Volume 8, Issue 3, September 2020
    Pages: 106-113
    Received: Jul. 08, 2020
    Accepted: Jul. 25, 2020
    Published: Sep. 24, 2020
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    Abstract: Uterine Leiomyoma are a very common benign tumors, affecting 20-30% of the female population over 35 years of age. Black women are the most affected compared to Caucasian women. In order to determine the genetic mecanisms involved in uterine fibroids in senegalese women, the study of penetrance of mutations of exon 4 of the gene was carried out. Ou... Show More
  • Rapid Molecular Identification of Tetraselmis Using Enzymatic Digestion of the 18S rDNA Gene

    Janeth Galarza, Kevin Crespín, Carolina Tufiño

    Issue: Volume 8, Issue 3, September 2020
    Pages: 114-119
    Received: Jul. 18, 2020
    Accepted: Aug. 17, 2020
    Published: Sep. 24, 2020
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    Abstract: Tetraselmis is a genus of quadriflagellated single-celled green algae belonging to the Phylum Chlorophyta, commonly used in aquaculture with very promising biotechnological potential. The varied morphological characteristics, in some cases, have led to confusion in taxonomic identification. To solve this problem, new techniques based on molecular m... Show More