International Journal of Genetics and Genomics

Volume 3, Issue 5, October 2015

  • Transgenerational Genetic Effect of Trichloroethane (TCE) on Phenotypic Variation of Acrosomal Proteolytic Enzyme and Male Infertility Risk

    Mohamed A. Al-Griw, Naser M. Salama, Soad A. Treesh, Abdul Hakim Elnfati

    Issue: Volume 3, Issue 5, October 2015
    Pages: 43-49
    Received: Aug. 19, 2015
    Accepted: Aug. 31, 2015
    Published: Sep. 09, 2015
    Abstract: Exposure to trichloroethane (TCE), a ambiguous environmental toxicant, has been negatively associated with male reproductive performance. The objective was to investigate, in-vivo, the mutagenic, carcinogenic or teratogenic effect of TCE maternal exposure on sperm quality and testicular cytoarchitecture of F1 generation of mice. A motile sperm sepa... Show More
  • Common MEFV Mutations in Palestinian Patients with Familial Mediterranean Fever

    Mohammed J. Ashour, Fadel A. Sharif

    Issue: Volume 3, Issue 5, October 2015
    Pages: 50-52
    Received: Aug. 26, 2015
    Accepted: Sep. 06, 2015
    Published: Sep. 14, 2015
    Abstract: Familial Mediterranean fever (FMF) is an autosomal recessive inflammatory disorder caused by mutations in the MEFV gene that encodes the pyrin protein. The disease is relatively common among people originating from the Mediterranean areas. The aim of this study was to determine the common MEFV gene mutations in 270 Palestinian patients diagnosed wi... Show More
  • Interleukin-6: A Proinflammatory Role in Nephritis in Patients with Systemic Lupus Erythematosus

    Dalia Abdul-Halim Shaheen, Hisham M. Habib, Mohamed A. Marie

    Issue: Volume 3, Issue 5, October 2015
    Pages: 53-58
    Received: Aug. 12, 2015
    Accepted: Aug. 28, 2015
    Published: Sep. 17, 2015
    Abstract: Background. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with a common finding of renal involvement which is related to high incidence of mortality and morbidity. IL-6 is produced by leukocytes and intrinsic kidney cells that affects inflammation, increases mesangial cell proliferation, and also contributes to autoimmunity. O... Show More