International Journal of Genetics and Genomics

Volume 6, Issue 1, March 2018

  • IDH1 Mutation in Gliomas in Baghdad by Immunohistochemical Study

    Zahraa Marwan Shaban, Salim Rasheed Al-Aubaidy, Ameer Dhahir Hameedi

    Issue: Volume 6, Issue 1, March 2018
    Pages: 1-7
    Received: Nov. 07, 2017
    Accepted: Nov. 20, 2017
    Published: Jan. 11, 2018
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    Abstract: IDH1 (isocitrate dehydrogenase 1) mutation might be encounter in the low-grade glioma occurs in early stages of development and directs the progression of the tumor to a higher grade. Aim of the study was to assess the frequency of IDH1 mutation in Iraqi patients with gliomas by immunohistochemical study, to correlate its immunoreactivity with some... Show More
  • 3D Diffraction – Limited Imaging with a Laser Fourier Holographic Microscope

    Vladimir Boris Karpov

    Issue: Volume 6, Issue 1, March 2018
    Pages: 8-10
    Received: Dec. 06, 2016
    Accepted: Aug. 17, 2017
    Published: Mar. 26, 2018
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    Abstract: A laser holographic microscope (LHM) is investigated experimentally. The standard slide of Parascaris Univalens Iarva (ascaris) is studied. Comparison of the pictures of the same ascaris cell, observed by the LHM and high-performance Nikon conventional optical microscope (COM) 10×100/1.25 with immersion oil and green filter indicates that the both ... Show More
  • A Systematic Genetic Assessment of ARFGEF2 Mutations in Periventricular Heterotopia

    Lina Al Neghery, Rosan Kenana, Albandary Al Bakheet, Rawan Al Mass, Faten Al Mutairi, Maysoon Al Sagob, Aliya Qari, Rozeena Huma, Dilek Colak, Maha Daghestani, Namik Kaya, Moeenaldeen Al Sayed

    Issue: Volume 6, Issue 1, March 2018
    Pages: 11-17
    Received: Jan. 12, 2018
    Accepted: Jan. 29, 2018
    Published: May 05, 2018
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    Abstract: Mutations in ADP-ribosylation factor guanine nucleotide-exchange factor 2 (ARFGEF2) lead to autosomal recessive periventricular heterotopia (PH). To date, 11 mutations, (six missense mutations, one splicing mutation, one small deletion, two small insertions, and one small deletion/insertion) have been reported. Assessing ARFGEF2 mutations will prov... Show More
  • A Small Pure 3q25.1 Duplication Associated with Multiple Cerebral Organizational Defects

    Jesus David Sendoya Vargas, Divya Periasamy, Frank Barreiro Sanchez, Maria Alejandra Benavides Fierro, Ingrid Carolina Duran Palacios, Richard Sidlow, Henry Ostos Alfonso

    Issue: Volume 6, Issue 1, March 2018
    Pages: 18-21
    Received: Mar. 11, 2018
    Accepted: Apr. 03, 2018
    Published: May 05, 2018
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    Abstract: Duplications of the long arm of chromosome 3 most frequently occur in the context of other chromosomal copy number variations. Pure duplications of this region are exceedingly rare, varying widely in size and clinical presentation. Presented below is a case of a small pure duplication of the long arm of chromosome 3q25.1 associated with marked cere... Show More