International Journal of Genetics and Genomics

Volume 5, Issue 5, October 2017

  • Frequency of L1721W Polymorphism in TET2 Gene Among a Cohort of Sudanese Patients with Myeloproliferative Disorders: Possible Roles in Pathogenicity and Leukemic Transformation

    Anas Abdelrahman Ibrahim, Eltahir Awad Gasim Khalil

    Issue: Volume 5, Issue 5, October 2017
    Pages: 49-53
    Received: Feb. 27, 2017
    Accepted: Apr. 21, 2017
    Published: Oct. 18, 2017
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    Abstract: Transformation of myeloproliferative disorders (MPDs) to acute leukemia is an evitable event that represents a stumbling block in the management of patients. The Janus Kinase-2 JAK2V617F mutation of MDP does not clarify the phenotypic variability observed in this disorder. But, a mutations in Ten-eleven-translocation-2 (TET2), a putative tumor supp... Show More
  • Lymphocyte Reproductive Activity Normalized to Numbers of Hematopoietic Stem Cells in Blood and Rate of Death in Fatal Diseases

    Aleksei N. Shoutko, Olga A. Gerasimova, Ludmila P. Ekimova, Fiodor Zherebtsov, Viktor F. Mus, Kirill S. Matyurin, Anatoly M. Granov

    Issue: Volume 5, Issue 5, October 2017
    Pages: 54-62
    Received: Jan. 29, 2017
    Accepted: Feb. 13, 2017
    Published: Oct. 18, 2017
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    Abstract: The numbers of CD133+ and CD31+ lymphocytes and those in the G2-M phases in the total fraction of circulating lymphocytes from patients with fatal liver cirrhosis and advanced lung cancer were investigated by flow cytometry during a long period of conventional treatment with OLT or palliative surgery followed by myelosuppressive chemotherapy. The r... Show More