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Prevalence of Interleukin-6-174 G/C and Interleukin-6-190 C/T Polymorphisms in Malnourished Children Aged 0-59 Months in Senegal

Malnutrition, which is one of the main causes of morbidity and mortality in children under five years of age worldwide, especially in developing and middle-income countries, constitutes a problem about which we have only minimal genetic comprehension. Interleukin 6 (IL6), a cytokine that regulates cell proliferation and differentiation as well as balance between the pro- and anti-inflammatory pathways, is reportedly associated with certain diseases in children, such as malnutrition, asthma, and obesity. The aim of this study was to evaluate the prevalence and distribution of IL6-174 G/C and IL6-190 C/T gene polymorphisms in malnourished children in Senegal. We analyzed polymorphisms IL6-174 G/C and IL6-190 C/T in 57 malnourished and 10 healthy children (age 0-59 months), using the polymerase chain reaction-restriction fragment length polymorphism assay. Z-score values were obtained using WHO Anthro® version 3.2.2 software. All data were entered into Excel spreadsheets and analyzed using R Studio version 4.2.2 software. Hardy Weinberg equilibrium, genotypic, and allelic frequencies were generated using GenePop version 4.3 software. Univariate logistic regression analysis was applied to determine the associations of the polymorphisms with malnutrition and anthropometry. The GG genotype was more frequent in the malnourished (84.44%) and healthy children (100%) for the IL6-174 polymorphism; whereas for IL6-190, the CC genotype was present in all healthy children (100%) and 89.47% malnourished children. The IL6-174 CC and IL6-190 TT genotypes were present only in 15.56% and 10.53% respectively in malnourished children. No heterozygous genotypes were found for either gene polymorphism. For the malnourished children, logistic regression analysis showed no significant associations between the IL6-174 and IL6-190 genotypes and the anthropometric measurements, whereas it did show significant associations (P < 0.05) of the IL6-174 GC and GG and IL6-190 CC genotypes with the female gender. It was concluded that IL6-174 G/C and IL6-190 C/T polymorphisms are not significantly associated with childhood malnutrition or anthropometric measurements.

Malnutrition, Children, IL6-174, IL6-190, Polymorphism

Jessika Issa, Fatimata Mbaye, Fatou Ly, Abdallah Diallo, Jean Baptiste Niokhor Diouf, et al. (2023). Prevalence of Interleukin-6-174 G/C and Interleukin-6-190 C/T Polymorphisms in Malnourished Children Aged 0-59 Months in Senegal. International Journal of Genetics and Genomics, 11(3), 91-96.

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